Switch to drug interaction data. Taking eszopiclone with a high-fat or heavy meal may delay the onset alprazolam sleep. For faster sleep onset, eszopiclone. Feb 10, - Lunesta is the brand name of the drug eszopiclone, which is used to treat insomnia. The medication is in a class of drugs called hypnotics. Lunesta drug interactions. Overview. eszopiclone. nonbenzodiazepine hypnotic. Interaction Characteristics: CYP3A4 substrate; CNS depression.